Protein Details: Potassium channel subfamily K member 16

Protein ID

ICDB_Pro_1413

Protein Name

Potassium channel subfamily K member 16

Gene Name

KCNK16; TALK1

Organism

Homo sapiens (Human)

Length

309 amino acids

AlphaFoldDB

AF-Q96T55-F1-model_v4.pdb

Function

Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents.

Sequence

MPSAGLCSCWGGRVLPLLLAYVCYLLLGATIFQLLERQAEAQSRDQFQLEKLRFLENYTCLDQWAMEQFVQVIMEAWVKGVNPKGNSTNPSNWDFGSSFFFAGTVVTTIGYGNLAPSTEAGQVFCVFYALLGIPLNVIFLNHLGTGLRAHLAAIERWEDRPRRSQVLQVLGLALFLTLGTLVILIFPPMVFSHVEGWSFSEGFYFAFITLSTIGFGDYVVGTDPSKHYISVYRSLAAIWILLGLAWLALILPLGPLLLHRCCQLWLLSLRQGCGAKAAPGRRPRRGSTAARGVQVTPQDFPISKKGLGS

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Birk-Barel Syndrome and Maturity-Onset Diabetes Of The Young

Location

Highly expressed in pancreas. Not detectable in the other tissues tested.

DOI ID

10.1006/bbrc.2001.4562; 10.1152/ajpcell.00601.2002; 10.1038/bjp.2008.213; 10.1038/nature02055; 10.1101/gr.2596504

RefSeq

NP_001128577.1 [Q96T55-4]; NP_001128578.1 [Q96T55-3]; NP_001128579.1 [Q96T55-5]; NP_115491.1 [Q96T55-1]; XP_016866835.1 [Q96T55-5]